Skip to content Learn about the access keys available for Aristotle.Cloud

Lung cancer immunohistochemistry type code N[N]

Definition

A code set representing immunohistochemical stains used to assist in the diagnosis of lung cancer.

Representation

Data Type Number
Format N[N]
Maximum character length 2

Values

Value Meaning Start Date End Date
Permissible Values 1 Thyroid transcription factor-1 (TTF-1)
2 Cytokeratin 5 (CK5)
3 Cytokeratin 6 (CK6)
4 Cytokeratin 7 (CK7)
5 Cytokeratin 20 (CK20)
6 p53-related transcription factor p63 (p63)
7 Napsin
88 Other
Supplementary Values 97 Not applicable-immunohistochemical staining not performed
98 Unknown if imunohistochemistry performed
99 Immunohistochemistry performed but stains not stated/inadequately described

Comments

Guide for use:
Record the code for each immunohistochemical profile obtained to assist in the diagnosis of lung cancer.

Comments:

Thyroid transcription factor-1 and cytokeratin 7 and 20 can be useful, in conjunction with tumour morphology and clinical and radiological findings, to help to distinguish between primary and metastatic lung adenocarcinomas.

Cytokeratin 5/6 and p63 immunostaining is used by some pathologists to help to determine whether a tumour is a squamous or non-squamous type.

The majority (about 75%) of primary lung adenocarcinomas are CK7 positive, CK20 negative and TTF-1 positive and Napsin stains are positive in approximately 80% of of primary lung adenocarcinomas.

References

Royal College of Pathologists of Australasia 2010. Lung cancer structured reporting protocol. 1st Edition (Version 1.0). Surry Hills, NSW: Royal College of Pathologists of Australasia
This content Based on Australian Institute of Health and Welfare material. Attribution provided as required under the AIHW CC-BY licence.

Related content

Relation Count
Data Elements implementing this Value Domain 1